The cortisol switch between vulnerability and resilience
ER de Kloet, M Joëls - Molecular Psychiatry, 2024 - nature.com
In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …
[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
EH Douma, ER de Kloet - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
[HTML][HTML] Coping with the forced swim stressor: Current state-of-the-art
ML Molendijk, ER de Kloet - Behavioural brain research, 2019 - Elsevier
The forced swim test (FST) for rodents does not model despair or helplessness. It also is not
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
a read-out for depression, anxiety, psychomotor retardation or autism, because these are …
[HTML][HTML] A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution
S Nardone, R De Luca, A Zito, N Klymko… - Nature …, 2024 - nature.com
Abstract The “dorsal pons”, or “dorsal pontine tegmentum”(dPnTg), is part of the brainstem. It
is a complex, densely packed region whose nuclei are involved in regulating many vital …
is a complex, densely packed region whose nuclei are involved in regulating many vital …
Glucocorticoid and mineralocorticoid receptors in the brain: a transcriptional perspective
ASCAM Koning, JC Buurstede… - Journal of the …, 2019 - academic.oup.com
Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …
Top‐down and bottom‐up control of stress‐coping
ER de Kloet, SF de Kloet, CS de Kloet… - Journal of …, 2019 - Wiley Online Library
In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic‐
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
prefrontocortical circuitry during stress‐coping. This action of the stress hormone is mediated …
Molecular ontology of the parabrachial nucleus
S Karthik, D Huang, Y Delgado, JJ Laing… - Journal of …, 2022 - Wiley Online Library
Diverse neurons in the parabrachial nucleus (PB) communicate with widespread brain
regions. Despite evidence linking them to a variety of homeostatic functions, it remains …
regions. Despite evidence linking them to a variety of homeostatic functions, it remains …
Central afferents to the nucleus of the solitary tract in rats and mice
S Gasparini, JM Howland, AJ Thatcher… - Journal of …, 2020 - Wiley Online Library
The nucleus of the solitary tract (NTS) regulates life‐sustaining functions ranging from
appetite and digestion to heart rate and breathing. It is also the brain's primary sensory …
appetite and digestion to heart rate and breathing. It is also the brain's primary sensory …
Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice
The parabrachial nucleus (PB) is a complex structure located at the junction of the midbrain
and hindbrain. Its neurons have diverse genetic profiles and influence a variety of …
and hindbrain. Its neurons have diverse genetic profiles and influence a variety of …
Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss
S Buller, C Blouet - American Journal of Physiology …, 2024 - journals.physiology.org
New incretin-based pharmacotherapies provide efficient and safe therapeutic options to
curb appetite and produce weight loss in patients with obesity. Delivered systemically, these …
curb appetite and produce weight loss in patients with obesity. Delivered systemically, these …