The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …

Alzheimer's disease (AD) is one of the most complicated progressive neurodegenerative
brain disorders, affecting millions of people around the world. Ageing remains one of the …

Alzheimer's disease (AD) is the most common form of dementia that remains incurable and
has become a major medical, social, and economic challenge worldwide. AD is …

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND)
comprise a group of illnesses marked by memory and behavioral dysfunction that can occur …

Background: Cognitive decline is a common consequence of COVID-19, and studies
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …

Highlights•The physiological and pathological pathogenesis of AD are outlined.•The
representative drug candidates for targeted therapy of AD and the binding mode with their …

Toosendanin (TSN) is a triterpenoid from the fruit or bark of Melia toosendan Sieb et Zucc,
which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity …

A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases
or cysteine proteases (CPs), are divided into three categories according to the peptide chain …

Alzheimer's disease (AD) is an important public health challenge with a limited
understanding of its pathogenesis. Smoking is a significant modifiable risk factor for AD …