Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

AL Flores-Mireles, JN Walker, M Caparon… - Nature reviews …, 2015 - nature.com
Urinary tract infections (UTIs) are a severe public health problem and are caused by a range
of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus …

Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …

Proteus mirabilis and Urinary Tract Infections

JN Schaffer, MM Pearson - Urinary tract infections: Molecular …, 2017 - Wiley Online Library
Proteus mirabilis is well known in clinical laboratories and microbiology survey courses as
the species that swarms across agar surfaces, overtaking any other species present in the …

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

HM Zowawi, PNA Harris, MJ Roberts… - Nature Reviews …, 2015 - nature.com
Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide,
the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or …

Adhesins involved in attachment to abiotic surfaces by Gram‐negative bacteria

C Berne, A Ducret, GG Hardy, YV Brun - Microbial biofilms, 2015 - Wiley Online Library
The ability of bacterial cells to adhere to and interact with surfaces to eventually form a
biofilm is a crucial trait for the survival of any microorganism in a complex environment. As a …

Global dissemination of a multidrug resistant Escherichia coli clone

NK Petty, NL Ben Zakour… - Proceedings of the …, 2014 - National Acad Sciences
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant
(MDR) clone responsible for a high proportion of urinary tract and bloodstream infections …

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

CN Spaulding, RD Klein, S Ruer, AL Kau, HL Schreiber… - Nature, 2017 - nature.com
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) affect 150
million people annually,. Despite effective antibiotic therapy, 30–50% of patients experience …

Urinary Tract Infections Caused by Uropathogenic Escherichia coli Strains—New Strategies for an Old Pathogen

C Zagaglia, MG Ammendolia, L Maurizi, M Nicoletti… - Microorganisms, 2022 - mdpi.com
Urinary tract infections (UTIs) are among the most common infections worldwide.
Uropathogenic Escherichia coli (UPECs) are the main causative agent of UTIs. UPECs …

How bacteria recognise and respond to surface contact

TEP Kimkes, M Heinemann - FEMS microbiology reviews, 2020 - academic.oup.com
Bacterial biofilms can cause medical problems and issues in technical systems. While a
large body of knowledge exists on the phenotypes of planktonic and of sessile cells in …