Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Most of the newly developed drug candidates are lipophilic and poorly water-soluble.
Enhancing the dissolution and bioavailability of these drugs is a major challenge for the …

Background Nanosuspensions, liquid dispersions with nanometer size distribution, are
becoming trendy in pharmaceutical practice to formulate poorly water-soluble drugs and to …

The transdermal application of actives offers numerous advantages over other conventional
routes. Namely, a stable level of drugs in the bloodstream and reduced side effects are the …

Sažetak Many modern drugs are poorly water soluble substances, which causes difficulties
in the development of solid dosage forms with sufficient bioavailability. Preparation of …

High specific surface area (SSA), porous structure, and suitable technological characteristics
(flow, compressibility) predetermine powder carriers to be used in pharmaceutical …

The first zwitterionic cocrystal of indomethacin (INC) with amino acid, INC–PL-H2O, where
PL represents L-proline, was prepared and thoroughly characterized by single crystal and …

This study aimed to enhance the dissolution of tadalafil, a poorly water-soluble drug by
applying liquisolid technique. The effects of two critical formulation variables, namely drug …

Hydrophobic drugs exhibit altered bioavailability and pose other challenges at an industrial
level due to their poor solubility and dissolution rates. In addition, poor flowability …

Liquisolid systems are an innovative dosage form used for enhancing dissolution rate and
improving in vivo bioavailability of poorly soluble drugs. These formulations require specific …