Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

Testicular tumours in dogs are of Sertoli cell, Leydig cell or germinal origin and mixed
tumours are also frequently observed. The cellular components of mixed tumours are …

Understanding how DNA is packaged in the mammalian sperm cell has important
implications for human infertility as well as for the cell biology. Recent advances in the study …

OBJECTIVE: To review and summarize the current understanding of the epigenetic status of
human sperm in regards to protamination, specific localization and modifications of retained …

During the elongating spermatid stage of spermiogenesis, human sperm chromatin
undergoes a complex transition in which histones are extensively replaced by protamines in …

A fascinating aspect of how chromatin structure impacts on gene expression and cellular
identity is the transmission of information from mother to daughter cells, independently of the …

During male germ cell postmeiotic maturation, dramatic chromatin reorganization occurs,
which is driven by completely unknown mechanisms. For the first time, we describe a …

A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an
important role in the chromatin reorganization required for meiosis and/or spermatogenesis …