Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

Despite the great effort that has gone into developing new molecules as multitarget
compounds to treat Alzheimer's disease (AD), none of these have been approved to treat …

Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and
degenerative neurological disorder characterized by loss of cognition and memory …

Abstract A novel series of 1, 3, 5‐trisubstituted‐2‐pyrazoline derivatives (4a‐4k) was
synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass …

In order to develop a potent antifungal agent, a carbothioamide-based pyrazoline derivative
(3a) was synthesized. Molecular structure of compound has been confirmed using …

Background: Considering that AD is multifactorial in nature, novel series of imidazo [2, 1-
b][1, 3, 4] thiadiazole derivatives were designed to address the basic factors responsible for …

The present work reports simple and effective protocol for preparing 6α-nitro-5α-cholestano
[7α, 5-cd] pyrazolines (4–7) by the reaction of 7α-bromo-6-nitrocholest-5-enes (1–3) with …

A novel series of 2-pyrazoline derivatives were designed, synthesized, and evaluated for
cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities. Among …

Alzheimer hastalığı genellikle davranışsal semptomlar ile bilişsel ve fiziksel işlev kaybı ile
karakterize ilerleyici ve nedeni bilinmeyen ölümcül bir demans türüdür. Plakların oluşumuna …

Demansın en yaygın nedeni olarak görülen Alzheimer hastalığı, bilişsel fonksiyonları
etkileyen progresif ve dejeneratif bir hastalıktır. Halen kullanılmakta olan tedaviler azalmış …