Targeting inflammation driven by HMGB1
High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell
types. It is a multi-facet protein exerting functions both inside and outside of cells …
types. It is a multi-facet protein exerting functions both inside and outside of cells …
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke
XY Xiong, L Liu, QW Yang - Progress in neurobiology, 2016 - Elsevier
Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …
damage. Their morphology and functional changes are correlated with the release of danger …
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
H Fan, HB Tang, Z Chen, HQ Wang, L Zhang… - Journal of …, 2020 - Springer
Background Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/
microglia-mediated response with only a transient appearance of anti-inflammatory …
microglia-mediated response with only a transient appearance of anti-inflammatory …
Extracellular HMGB1 as a therapeutic target in inflammatory diseases
U Andersson, H Yang, H Harris - Expert opinion on therapeutic …, 2018 - Taylor & Francis
Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …
promotes inflammation when released extracellularly after cellular activation, stress …
HMGB1: a common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction
High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia
and neurons upon inflammasome activation and activates receptor for advanced glycation …
and neurons upon inflammasome activation and activates receptor for advanced glycation …
Interleukin-17 in chronic inflammatory neurological diseases
J Milovanovic, A Arsenijevic, B Stojanovic… - Frontiers in …, 2020 - frontiersin.org
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …
Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling
Neuronal dysfunction initiates several intracellular signaling cascades to release different
proinflammatory cytokines and chemokines, as well as various reactive oxygen species. In …
proinflammatory cytokines and chemokines, as well as various reactive oxygen species. In …
Translational research in traumatic brain injury
D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …
contributing to nearly one-third of all injury related deaths in the United States and exacting …
The role of IL-17 in CNS diseases
Cytokines of the IL-17 family are uniquely placed on the border between immune cells and
tissue. Although IL-17 was originally found to induce the activation and mobilization of …
tissue. Although IL-17 was originally found to induce the activation and mobilization of …
HMGB1 as biomarker and drug target
E Venereau, F De Leo, R Mezzapelle… - Pharmacological …, 2016 - Elsevier
Abstract High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has
a⿿ second life⿿ outside the cell where it acts as a damage-associated molecular pattern …
a⿿ second life⿿ outside the cell where it acts as a damage-associated molecular pattern …