Exosomes: roles and therapeutic potential in osteoarthritis

Z Ni, S Zhou, S Li, L Kuang, H Chen, X Luo, J Ouyang… - Bone research, 2020 - nature.com
Exosomes participate in many physiological and pathological processes by regulating cell–
cell communication, which are involved in numerous diseases, including osteoarthritis (OA) …

[HTML][HTML] Inflammation in joint injury and post-traumatic osteoarthritis

J Lieberthal, N Sambamurthy, CR Scanzello - Osteoarthritis and cartilage, 2015 - Elsevier
Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and
progression of disease. Signs of inflammation can be observed in joint fluids and tissues …

Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology

S Tang, L Yao, J Ruan, J Kang, Y Cao, X Nie… - Science Translational …, 2024 - science.org
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint
homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional …

[HTML][HTML] Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

F Berenbaum - Osteoarthritis and cartilage, 2013 - Elsevier
Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …

Inflammation in osteoarthritis

MB Goldring, M Otero - Current opinion in rheumatology, 2011 - journals.lww.com
Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

J Sokolove, CM Lepus - Therapeutic advances in …, 2013 - journals.sagepub.com
Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

[HTML][HTML] The role of macrophages in osteoarthritis and cartilage repair

CL Wu, NS Harasymowicz, MA Klimak… - Osteoarthritis and …, 2020 - Elsevier
Osteoarthritis (OA) is a family of degenerative diseases affecting multiple joint tissues.
Despite the diverse etiology and pathogenesis of OA, increasing evidence suggests that …

[HTML][HTML] Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I

B Heidari - Caspian journal of internal medicine, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) a common disease of aged population and one of the leading causes of
disability. Incidence of knee OA is rising by increasing average age of general population …

[HTML][HTML] Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

BJE De Lange-Brokaar, A Ioan-Facsinay… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

G Wei, K Lu, M Umar, Z Zhu, WW Lu, JR Speakman… - Bone Research, 2023 - nature.com
Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …