The treat-to-target (T2T) concept has improved outcomes for patients with diabetes,
hypertension and rheumatoid arthritis. This therapeutic strategy involves choosing a well …

Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that can
cause injury in almost every body system. While considered a classic example of …

Background Treat-to-target goals for patients with systemic lupus erythematosus (SLE) have
been validated to protect against organ damage and to improve quality of life. We aimed to …

Objective To determine the independent impact of different definitions of remission and low
disease activity (LDA) on damage accrual. Methods Patients with≥ 2 annual assessments …

Objectives In patients with systemic lupus erythematosus (SLE), lupus low disease activity
state (LLDAS) attainment is associated with improved outcomes. We investigated LLDAS …

Treat-to-target strategies have changed the approach to management of many chronic
conditions, with improvements in patient outcomes. The key to success of treat to target is …

Background Remission and low disease activity (LDA) have been proposed as the treatment
goals for patients with systemic lupus erythematosus (SLE). Several definitions for each …

Objective To achieve a consensus-based definition of Low Disease Activity (LDA) for use in
cSLE trials. Methods The International cSLE T2T Task Force, comprising of paediatric …

Abstract Purpose of Review Discuss the prognostic significance of kidney flares in patients
with lupus nephritis, associated risk factors, and possible preventative strategies. Recent …

Objectives To assess the achievability and effect of attaining low disease activity (LDA) or
remission in childhood-onset SLE (cSLE). Methods Attainment of three adult-SLE derived …