The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …

Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells
to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is …

Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of
the mammalian placenta, however, the contribution of ERVs to placental development and …

Our ability to study early human post-implantation development remains highly limited due
to the ethical and technical challenges associated with intrauterine development of the …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

Trophoblast stem cells (TSCs) are a proliferative multipotent population derived from the
trophectoderm of the blastocyst, which will give rise to all the functional cell types of the …

Background The placenta is an extraembryonic organ, which is essential to maintain a
normal pregnancy. However, placental development in humans is poorly understood …

Histone variants are the paralogs of core histones (H2A, H2B, H3 and H4). They are stably
expressed throughout the cell cycle in a replication-independent fashion and are capable of …

Endogenous retroviruses (ERVs) in the mammalian genome play diverse roles in embryonic
development. These developmentally related ERVs are generally repressed in somatic cells …