Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Primary congenital glaucoma (PCG) is an autosomal-recessive condition characterized by
high intraocular pressure (IOP), usually within the first year of life, which potentially could …

Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder …

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma
and is the only target for current glaucoma therapy. The genetic factors which determine IOP …

Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive
trait, or as a complex multifactorial trait. Genetic approaches have helped define the …

Background Context-specific evidence of the spectrum of type 2 diabetes (T2D) burden is
essential for setting priorities and designing interventions to reduce associated morbidity …

Glaucoma, a leading cause of blindness worldwide, is characterized by progressive optic
nerve damage, usually associated with intraocular pressure. Although the clinical …

Background Glaucoma is the leading cause of irreversible blindness worldwide. There tends
to be a lower reporting of glaucoma in Africa compared to other blinding conditions in global …

Seemingly unaffected siblings of children with CYP1B1-related primary congenital/infantile
glaucoma should undergo genetic testing because of variable expressivity for the …