Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
M Croft, RM Siegel - Nature Reviews Rheumatology, 2017 - nature.com
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …
[HTML][HTML] TNF superfamily control of tissue remodeling and fibrosis
H Steele, J Cheng, A Willicut, G Dell… - Frontiers in …, 2023 - frontiersin.org
Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause
of death in USA. Despite major advances in recent years, there remains an unmet need to …
of death in USA. Despite major advances in recent years, there remains an unmet need to …
[HTML][HTML] Realigning the LIGHT signaling network to control dysregulated inflammation
CF Ware, M Croft, GA Neil - The Journal of Experimental Medicine, 2022 - ncbi.nlm.nih.gov
Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …
Genetics of primary sclerosing cholangitis and pathophysiological implications
X Jiang, TH Karlsen - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …
[HTML][HTML] Thymic stromal lymphopoietin in cutaneous immune-mediated diseases
SH Wang, YG Zuo - Frontiers in Immunology, 2021 - frontiersin.org
Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating
inflammatory responses among various allergic disorders (such as atopic dermatitis, food …
inflammatory responses among various allergic disorders (such as atopic dermatitis, food …
MiR-326 inhibits inflammation and promotes autophagy in silica-induced pulmonary fibrosis through targeting TNFSF14 and PTBP1
T Xu, W Yan, Q Wu, Q Xu, J Yuan, Y Li… - Chemical Research …, 2019 - ACS Publications
Silicosis is a kind of irreversible pulmonary fibrosis induced by the long-term inhalation of
silica particles. The therapeutic strategy based on the microRNAs might be an effective way …
silica particles. The therapeutic strategy based on the microRNAs might be an effective way …
A deficiency in the cytokine TNFSF14/LIGHT limits inflammation and remodeling in murine eosinophilic esophagitis
MC Manresa, H Miki, J Miller, K Okamoto… - The Journal of …, 2022 - journals.aai.org
Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …
[HTML][HTML] Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions
SL Hsieh, WW Lin - Journal of biomedical science, 2017 - Springer
Abstract Decoy receptor 3 (DcR3), also known as tumor necrosis factor receptor (TNFR)
superfamily member 6b (TNFRSF6B), is a soluble decoy receptor which can neutralize the …
superfamily member 6b (TNFRSF6B), is a soluble decoy receptor which can neutralize the …
[HTML][HTML] Inflammation and interferon signatures in peripheral B-lymphocytes and sera of individuals with fibromyalgia
S Fineschi, J Klar, KA Gustafsson, K Jonsson… - Frontiers in …, 2022 - frontiersin.org
Fibromyalgia (FM) is an idiopathic chronic disease characterized by widespread
musculoskeletal pain, hyperalgesia and allodynia, often accompanied by fatigue, cognitive …
musculoskeletal pain, hyperalgesia and allodynia, often accompanied by fatigue, cognitive …
Increased production of LIGHT by T cells in eosinophilic esophagitis promotes differentiation of esophageal fibroblasts toward an inflammatory phenotype
MC Manresa, AWT Chiang, RC Kurten, R Dohil… - Gastroenterology, 2020 - Elsevier
Background & Aims Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …