TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause
of death in USA. Despite major advances in recent years, there remains an unmet need to …

Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating
inflammatory responses among various allergic disorders (such as atopic dermatitis, food …

Silicosis is a kind of irreversible pulmonary fibrosis induced by the long-term inhalation of
silica particles. The therapeutic strategy based on the microRNAs might be an effective way …

Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to …

Abstract Decoy receptor 3 (DcR3), also known as tumor necrosis factor receptor (TNFR)
superfamily member 6b (TNFRSF6B), is a soluble decoy receptor which can neutralize the …

Fibromyalgia (FM) is an idiopathic chronic disease characterized by widespread
musculoskeletal pain, hyperalgesia and allodynia, often accompanied by fatigue, cognitive …

Background & Aims Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …