Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize
previous findings that serotonin regulates executive function, sensory gating, and social …

Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here …

Background and aims Establishment of the gut microbiota is one of the most important
events in early life and emerging evidence indicates that the gut microbiota influences …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

The central nervous system is highly enriched in long-chain polyunsaturated fatty acid
(PUFA) of the omega-6 and omega-3 series. The presence of these fatty acids as structural …

Depression is one of the most common neuropsychiatric disorders and has been associated
with the neuroendocrine system and alterations in specific brain proteins. Resveratrol is a …