Synthesis and antimycobacterial activity of triterpenic A-ring azepanes

NI Medvedeva, OB Kazakova, TV Lopatina… - European Journal of …, 2018 - Elsevier
A series of A-ring azepanones and azepanes derived from betulonic, oleanonic and ursonic
acids was synthesized and evaluated for their in vitro antimycobacterial activities against M …

Synthesis of A-ring quinolones, nine-membered oxolactams and spiroindoles by oxidative transformations of 2, 3-indolotriterpenoids

EF Khusnutdinova, OB Kazakova, AN Lobov… - Organic & …, 2019 - pubs.rsc.org
This paper describes an access to new nitrogen-containing heterocyclic triterpenoids by the
reaction of 2, 3-indolotriterpenoids with ozone and dimethyldioxirane. The oxidation of …

Transformations of pentacyclic triterpenoids as a route to the future medicines

LA Baltina, NG Komissarova - Studies in Natural Products Chemistry, 2023 - Elsevier
Plant-derived natural products (plant secondary metabolites) are an inexhaustible source for
the new bioactive substances due to the large structural diversity and a broad spectrum of …

Synthesis and antimalarial activity of 3′-trifluoromethylated 1, 2, 4-trioxolanes and 1, 2, 4, 5-tetraoxane based on deoxycholic acid

EY Yamansarov, DV Kazakov, IM Natal'ya… - Steroids, 2018 - Elsevier
A series of new steroidal peroxides–3′-trifluoromethylated 1, 2, 4-trioxolanes and 1, 2, 4, 5-
tetraoxanes based on deoxycholic acid were prepared via the reactions of the Griesbaum …

Synthesis and cytotoxicity of 28-oxo-allobetulone derivatives

EF Khusnutdinova, IE Smirnova… - Chemistry of Natural …, 2020 - Springer
28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by
modification of ring A (3-and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone …

A late-stage diversification via Heck-Matsuda arylation: Straightforward synthesis and cytotoxic/antiproliferative profiling of novel aryl-labdane-type derivatives

J de Souza-Ferrari, EA Silva-Júnior, JA Vale… - Bioorganic & Medicinal …, 2021 - Elsevier
In the current study a late-stage diversification of unactivated olefins labd-8 (17)-en-15-oic
acid (1a) and methyl labd-8 (17)-en-15-oate (1b) via Heck-Matsuda arylation is described …

Seven-membered rings

AG Meyer, AC Bissember, CJT Hyland… - Progress in Heterocyclic …, 2018 - Elsevier
New synthetic methods to prepare seven-membered heterocyclic compounds containing
one, two, or three of the heteroatoms N, O or S are covered. Aromatic systems containing at …

Oxidation of 3β-Acetoxy-21β-acetyl-20β,28-epoxy-18α,19βH-ursane into Novel gem-Chloronitro- and 1,2,4,5-tetraoxane derivatives

EY Yamansarov, EF Khusnutdinova… - Natural Product …, 2018 - journals.sagepub.com
The first oxidative transformations of 3β-acetoxy-21β-acetyl-20β, 28-epoxy-18α, 19β H-
ursane at the 21β-acetyl reaction center were performed. Ursane-type 1, 2, 4, 5-tetraoxanes …

[PDF][PDF] Синтез новых N-, O-содержащих гетероциклов на основе оксопроизводных пентациклических тритерпеноидов: диссертация на соискание ученой …

МА Назаров - 2023 - elar.urfu.ru
Актуальность темы. Пентациклические тритерпеноиды успешно зарекомендовали
себя в качестве перспективных структурных платформ для получения биологически …