Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

Non-resolving inflammation drives the development of clinically dangerous atherosclerotic
lesions by promoting sustained plaque inflammation, large necrotic cores, thin fibrous caps …

Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …