Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

Homeobox genes encode transcription factors that play essential roles in controlling cell
growth and differentiation during embryonic development. Many homeobox genes are …

Genetic changes underlie tumor progression and may lead to cancer-specific expression of
critical genes. Over 1100 publications have described the use of comparative genomic …

Epithelial-mesenchymal transition (EMT) is increasingly recognized as a mechanism
whereby cells in primary noninvasive tumors acquire properties essential for migration and …

We propose the hypothesis that loss of estrogen receptor function which leads to endocrine
resistance in breast cancer, also results in trans-differentiation from an epithelial to a …

HOX genes encode transcription factors that control patterning and cell fates. Alterations in
HOX expression have been clearly implicated in leukemia, but their role in most other …

Purpose: This study was to investigate the clinicopathologic significance and potential role
of HOXB7 in the development and progression of colorectal cancer (CRC). Experimental …

The molecular events that lead to the cancer-initiating cell involve critical mutations in genes
regulating normal cell growth and differentiation. Cancer stem cells, or cancer initiating cells …

We had demonstrated previously a functional bridge between altered homebox (HOX) gene
expression and tumor progression through HOXB7 transactivation of basic fibroblast growth …

Increased mammary epithelial expression of the human growth hormone (hGH) gene is
associated with the acquisition of pathological proliferation. We report here that autocrine …