Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

This article offers a reformulation of the negative reinforcement model of drug addiction and
proposes that the escape and avoidance of negative affect is the prepotent motive for …

This transdisciplinary review of the literature addresses the questions, Do stress and
negative affect (NA) promote smoking? and Does smoking genuinely relieve stress and NA …

This article updates a 1990 review of the effects of tobacco abstinence by reviewing (a)
which symptoms are valid indicators of tobacco abstinence and (b) the time course of …

Tobacco smoking results in more than five million deaths each year and accounts for∼ 90%
of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke …

An emerging body of research suggests that mindfulness-based interventions may be
beneficial for smoking cessation and the treatment of other addictive disorders. One way that …

Abstract The Relapse Prevention (RP) model has been a mainstay of addictions theory and
treatment since its introduction three decades ago. This paper provides an overview and …

Background and rationale The reinstatement model is widely used to study relapse to drug
addiction. However, the model's validity is open to question. Objective We assess the …

Relapse is a central problem in smoking treatment. Data collected at the time of relapse
episodes indicate that stress and negative affect (NA) promote relapse, but retrospective …

Smokers of any age can reap substantial health benefits by quitting. In fact, no other single
public health effort is likely to achieve a benefit comparable to large-scale smoking …