ABC transporter-mediated multidrug-resistant cancer

H Amawi, HM Sim, AK Tiwari, SV Ambudkar… - Drug transporters in …, 2019 - Springer
ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland

E Knop, N Knop, T Millar, H Obata… - … & visual science, 2011 - iovs.arvojournals.org
The tarsal glands of Meibom (glandulae tarsales) are large sebaceous glands located in the
eyelids and, unlike those of the skin, are unassociated with hairs. According to Duke-Elder …

[HTML][HTML] p53 represses the mevalonate pathway to mediate tumor suppression

SH Moon, CH Huang, SL Houlihan, K Regunath… - Cell, 2019 - cell.com
There are still gaps in our understanding of the complex processes by which p53
suppresses tumorigenesis. Here we describe a novel role for p53 in suppressing the …

Atherosclerosis: the road ahead

CK Glass, JL Witztum - Cell, 2001 - cell.com
Lipoproteins and Atherosclerosis Christopher K. Glass*†‡ and Joseph L. Witztum*
Specialized Center of Research on Molecular Serum cholesterol is carried by several …

Role of oxidative modifications in atherosclerosis

R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

The role of apolipoprotein E in Alzheimer's disease

J Kim, JM Basak, DM Holtzman - Neuron, 2009 - cell.com
The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

KE Berge, H Tian, GA Graf, L Yu, NV Grishin, J Schultz… - Science, 2000 - science.org
In healthy individuals, acute changes in cholesterol intake produce modest changes in
plasma cholesterol levels. A striking exception occurs in sitosterolemia, an autosomal …

Molecular basis of cholesterol efflux via ABCG subfamily transporters

Y Sun, J Wang, T Long, X Qi… - Proceedings of the …, 2021 - National Acad Sciences
The ABCG1 homodimer (G1) and ABCG5–ABCG8 heterodimer (G5G8), two members of the
adenosine triphosphate (ATP)–binding cassette (ABC) transporter G family, are required for …

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

MA Kennedy, GC Barrera, K Nakamura, Á Baldán… - Cell metabolism, 2005 - cell.com
Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid
homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to …

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

G Chinetti, S Lestavel, V Bocher, AT Remaley… - Nature medicine, 2001 - nature.com
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate lipid
and glucose metabolism and cellular differentiation. PPAR-α and PPAR-γ are both …