Traditional and new influenza vaccines
SS Wong, RJ Webby - Clinical microbiology reviews, 2013 - Am Soc Microbiol
The challenges in successful vaccination against influenza using conventional approaches
lie in their variable efficacy in different age populations, the antigenic variability of the …
lie in their variable efficacy in different age populations, the antigenic variability of the …
Cytotoxic CD4 T cells—friend or foe during viral infection?
JA Juno, D Van Bockel, SJ Kent, AD Kelleher… - Frontiers in …, 2017 - frontiersin.org
CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in
vitro cultures but have in more recent years become accepted and reported in the literature …
vitro cultures but have in more recent years become accepted and reported in the literature …
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses
Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …
[HTML][HTML] CD4+ Cytotoxic T cells–phenotype, function and transcriptional networks controlling their differentiation pathways
T Preglej, W Ellmeier - Immunology Letters, 2022 - Elsevier
The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …
The quest for a truly universal influenza vaccine
YH Jang, BL Seong - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
There is an unmet public health need for a universal influenza vaccine (UIV) to provide
broad and durable protection from influenza virus infections. The identification of broadly …
broad and durable protection from influenza virus infections. The identification of broadly …
Virus-specific T cells as correlate of (cross-) protective immunity against influenza
Since inactivated influenza vaccines mainly confer protective immunity by inducing strain-
specific antibodies to the viral hemagglutinin, these vaccines only afford protection against …
specific antibodies to the viral hemagglutinin, these vaccines only afford protection against …
Influenza B viruses: not to be discounted
CE Van De Sandt, R Bodewes… - Future …, 2015 - Taylor & Francis
In contrast to influenza A viruses, which have been investigated extensively, influenza B
viruses have attracted relatively little attention. However, influenza B viruses are an …
viruses have attracted relatively little attention. However, influenza B viruses are an …
Sequential immunization with live-attenuated chimeric hemagglutinin-based vaccines confers heterosubtypic immunity against influenza A viruses in a preclinical …
WC Liu, R Nachbagauer, D Stadlbauer… - Frontiers in …, 2019 - frontiersin.org
Due to continuous antigenic drift and occasional antigenic shift, influenza viruses escape
from human adaptive immunity resulting in significant morbidity and mortality in humans …
from human adaptive immunity resulting in significant morbidity and mortality in humans …
T cell immunity against influenza: The long way from animal models towards a real-life universal flu vaccine
A Schmidt, D Lapuente - Viruses, 2021 - mdpi.com
Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …
leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains …
Progress on chicken T cell immunity to viruses
M Dai, C Xu, W Chen, M Liao - Cellular and Molecular Life Sciences, 2019 - Springer
Avian virus infection remains one of the most important threats to the poultry industry.
Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and …
Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and …