With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

Woese and Fox's 1977 paper on the discovery of the Archaea triggered a revolution in the
field of evolutionary biology by showing that life was divided into not only prokaryotes and …

Eukaryotic life appears to have flourished surprisingly late in the history of our planet. This
view is based on the low diversity of diagnostic eukaryotic fossils in marine sediments of mid …

Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

Plant–microbe interactions in the rhizosphere have important roles in biogeochemical
cycling, and maintenance of plant health and productivity, yet remain poorly understood …

Technological developments, especially in mass spectrometry and bioinformatics, have
revealed that living cells contain thousands rather than dozens of different lipids [for …

Cholesterol and its relatives possessing the 1, 2-cyclopentanoperhydrophenanthrene ring
system (Figure 1) form the sterolome, which comprises a chemical library of more than 1000 …

Planctomycetes form a distinct phylum of the domain Bacteria and possess unusual features
such as intracellular compartmentalization and a lack of peptidoglycan in their cell walls …

For at least 1.2 billion years, eukaryotes have been able to synthesize sterols and, therefore,
can produce vitamin D when exposed to UV-B. Vitamin D endocrinology was established …

Despite its importance for mammalian cell biology and human health, there are many basic
aspects of cholesterol homeostasis that are not well understood. Even for the well …