[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
[HTML][HTML] Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners
M Šrejber, V Navrátilová, M Paloncýová… - Journal of inorganic …, 2018 - Elsevier
Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
NADPH P450 oxidoreductase: structure, function, and pathology of diseases
Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …
NADPH–cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family
NADPH–cytochrome P450 oxidoreductase (CYPOR) and nitric oxide synthase (NOS), two
members of the diflavin oxidoreductase family, are multi-domain enzymes containing distinct …
members of the diflavin oxidoreductase family, are multi-domain enzymes containing distinct …
Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase
V Agrawal, JH Choi, KM Giacomini… - Pharmacogenetics and …, 2010 - journals.lww.com
Objectives CYP3A4 receives electrons from P450 oxidoreductase (POR) to metabolize
about 50% of clinically used drugs. There is substantial inter-individual variation in CYP3A4 …
about 50% of clinically used drugs. There is substantial inter-individual variation in CYP3A4 …
P450 Oxidoreductase deficiency: analysis of mutations and polymorphisms
Cytochrome P450 oxidoreductase (POR) is required for metabolic reactions of steroid and
drug metabolizing cytochrome P450 proteins located in endoplasmic reticulum. Mutations in …
drug metabolizing cytochrome P450 proteins located in endoplasmic reticulum. Mutations in …
Pharmacogenomics of human P450 oxidoreductase
AV Pandey, P Sproll - Frontiers in pharmacology, 2014 - frontiersin.org
Cytochrome P450 oxidoreductase (POR) supports reactions of microsomal cytochrome
P450 which metabolize drugs and steroid hormones. Mutations in POR cause disorders of …
P450 which metabolize drugs and steroid hormones. Mutations in POR cause disorders of …
Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders
Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …
epoxygenases are actively involved in the metabolism of endogenous substances, like …
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency
NADPH-cytochrome P450 oxidoreductase (CYPOR) is essential for electron donation to
microsomal cytochrome P450-mediated monooxygenation in such diverse physiological …
microsomal cytochrome P450-mediated monooxygenation in such diverse physiological …
Role of protein–protein interactions in cytochrome P450-mediated drug metabolism and toxicity
SE Kandel, JN Lampe - Chemical research in toxicology, 2014 - ACS Publications
Through their unique oxidative chemistry, cytochrome P450 monooxygenases (CYPs)
catalyze the elimination of most drugs and toxins from the human body. Protein–protein …
catalyze the elimination of most drugs and toxins from the human body. Protein–protein …