Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport
machine capable of long-distance processive movement along microtubules. However, it is …

Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report
the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Intracellular transport is the basis of microscale logistics within cells and is powered by
biomolecular motors. Mimicking transport for in vitro applications has been widely studied; …

ABSTRACT Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that
drives the movement of diverse cargos along the microtubule cytoskeleton, including …

Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …

Kinesin and dynein motors transport intracellular cargos bidirectionally by pulling them in
opposite directions along microtubules, through a process frequently described as a 'tug of …