Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
AL Burns, MG Dans, JM Balbin… - FEMS microbiology …, 2019 - academic.oup.com
Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …
burden. With the spread of parasites resistant to artemisinin combination therapies in …
Towards next-generation treatment options to combat Plasmodium falciparum malaria
Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …
The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei
R Rashpa, N Klages, D Schvartz, C Pasquarello… - Nature …, 2023 - nature.com
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental
phases in the human and the mosquito hosts, regulated by various post-translational …
phases in the human and the mosquito hosts, regulated by various post-translational …
Three F-actin assembly centers regulate organelle inheritance, cell-cell communication and motility in Toxoplasma gondii
N Tosetti, N Dos Santos Pacheco, D Soldati-Favre… - Elife, 2019 - elifesciences.org
Toxoplasma gondii possesses a limited set of actin-regulatory proteins and relies on only
three formins (FRMs) to nucleate and polymerize actin. We combined filamentous actin (F …
three formins (FRMs) to nucleate and polymerize actin. We combined filamentous actin (F …
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
A Patel, AJ Perrin, HR Flynn, C Bisson… - PLoS …, 2019 - journals.plos.org
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …
Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite
Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …
Parasite and host kinases as targets for antimalarials
ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …
transmission control measures led to a decrease in the global malaria burden over the …
Plasmodium falciparum calcium-dependent protein kinase 4 is critical for male gametogenesis and transmission to the mosquito vector
Gametocytes of the malaria parasite Plasmodium are taken up by the mosquito vector with
an infectious blood meal, representing a critical stage for parasite transmission. Calcium …
an infectious blood meal, representing a critical stage for parasite transmission. Calcium …
Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
Apicomplexan parasites use Ca 2+-regulated exocytosis to secrete essential virulence
factors from specialized organelles called micronemes. Ca 2+-dependent protein kinases …
factors from specialized organelles called micronemes. Ca 2+-dependent protein kinases …
Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum
The human malaria parasite Plasmodium falciparum requires efficient egress out of an
infected red blood cell for pathogenesis. This egress event is highly coordinated and is …
infected red blood cell for pathogenesis. This egress event is highly coordinated and is …