The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

The conducted vasomotor response and the principles of electrical communication in resistance arteries

GY Mironova, PM Kowalewska… - Physiological …, 2024 - journals.physiology.org
Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

Mechanisms of connexin-related lymphedema: a critical role for Cx45, but not Cx43 or Cx47, in the entrainment of spontaneous lymphatic contractions

JA Castorena-Gonzalez, SD Zawieja, M Li… - Circulation …, 2018 - Am Heart Assoc
Rationale: Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively,
are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient …

Tubuloglomerular feedback synchronization in nephrovascular networks

T Zehra, WA Cupples, B Braam - Journal of the American Society …, 2021 - journals.lww.com
To perform their functions, the kidneys maintain stable blood perfusion in the face of
fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic …

The conducted vasomotor response: function, biophysical basis, and pharmacological control

DG Welsh, CHT Tran, BO Hald… - Annual review of …, 2018 - annualreviews.org
Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ
function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli …

Electrical communication in lymphangions

BO Hald, JA Castorena-Gonzalez, SD Zawieja, P Gui… - Biophysical …, 2018 - cell.com
Contractions of lymphangions, ie, the segment between two one-way lymphatic valves,
generate the pressure gradients that propel lymph back to the circulation. Each lymphangion …

[HTML][HTML] The conducted vascular response as a mediator of hypercapnic cerebrovascular reactivity: a modelling study

A Daher, S Payne - Computers in Biology and Medicine, 2024 - Elsevier
It is well established that the cerebral blood flow (CBF) shows exquisite sensitivity to
changes in the arterial blood partial pressure of CO 2 (P a, CO 2), which is reflected by an …

Myoendothelial coupling through Cx40 contributes to EDH‐induced vasodilation in murine renal arteries: evidence from experiments and modelling

JC Brasen, C de Wit, CM Sorensen - Acta Physiologica, 2018 - Wiley Online Library
Regulation of renal vascular resistance plays a major role in controlling arterial blood
pressure. The endothelium participates in this regulation as endothelial derived …

Involvement of connexin 43 phosphorylation and gap junctional communication between smooth muscle cells in vasopressin-induced ROCK-dependent …

G Yang, X Peng, Y Wu, T Li… - American Journal of …, 2017 - journals.physiology.org
We examined the roles played by gap junctions (GJs) and the GJ channel protein connexin
43 (Cx43) in arginine vasopressin (AVP)-induced vasoconstriction after hemorrhagic shock …

Molecular regulation of myoendothelial gap junctions

K Pogoda, P Kameritsch - Current opinion in pharmacology, 2019 - Elsevier
Highlights•MEGJ are differentially regulated dependent on their connexin
composition.•MEGJ are regulated through post-translational modifications of vascular …