Basics of androgen synthesis and action
Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …
predominant androgen in males, while in adult females, T concentrations are about 15-fold …
Targeting sex steroid biosynthesis for breast and prostate cancer therapy
M Poutanen, M Hagberg Thulin, P Härkönen - Nature Reviews Cancer, 2023 - nature.com
Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …
by Poutanen et al. describes the development of treatments for these cancer types that act to …
Bacterial steroid-17, 20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1, 4-androstanediene-3, 11, 17-trione, a metabolite that …
The adrenal gland has traditionally been viewed as a source of “weak androgens”; however,
emerging evidence indicates 11-oxy-androgens of adrenal origin are metabolized in …
emerging evidence indicates 11-oxy-androgens of adrenal origin are metabolized in …
A quantitative analysis of total and free 11-oxygenated androgens and its application to human serum and plasma specimens using liquid-chromatography tandem …
P Caron, V Turcotte, C Guillemette - Journal of Chromatography A, 2021 - Elsevier
Abstract Bioactive 11-oxygenated C 19 adrenal-derived steroids (11-oxy C 19) are
potentially relevant in diverse endocrine and metabolic contexts. We report the development …
potentially relevant in diverse endocrine and metabolic contexts. We report the development …
Back where it belongs: 11β-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis
Adrenal steroidogenesis has, for decades, been depicted as three biosynthesis pathways–
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …
Gut feelings about bacterial steroid-17, 20-desmolase
Advances in technology are only beginning to reveal the complex interactions between
hosts and their resident microbiota that have co-evolved over centuries. In this review, we …
hosts and their resident microbiota that have co-evolved over centuries. In this review, we …
Sensitive HPLC-DMS/MS/MS method coupled with dispersive magnetic solid phase extraction followed by in situ derivatization for the simultaneous determination of …
X Zhang, H Xu, G Feng, L Yang, L Zhao, R Li… - Clinica Chimica Acta, 2023 - Elsevier
Background and aims Androgens play important roles in polycystic ovarian syndrome
(PCOS). However, measures of androgens based on mass spectrometry (MS) remain …
(PCOS). However, measures of androgens based on mass spectrometry (MS) remain …
C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors
C11-oxy C19 and C11-oxy C21 steroids have been identified as novel steroids but their
function remains unclear. This study aimed to investigate the pre-receptor regulation of C11 …
function remains unclear. This study aimed to investigate the pre-receptor regulation of C11 …
Circulating adrenal 11-oxygenated androgens are associated with clinical outcome in endometrial cancer
C Dahmani, P Caron, D Simonyan, V Turcotte… - Frontiers in …, 2023 - frontiersin.org
Context Recent evidence support that androgens play an important role in the etiology of
endometrial cancer (EC). Adrenal-derived 11-oxygenated androgens are highly potent …
endometrial cancer (EC). Adrenal-derived 11-oxygenated androgens are highly potent …
CYP17A1 exhibits 17αhydroxylase/17, 20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway
Abstract Cytochrome P450 17α-hydroxylase/17, 20-lyase (CYP17A1) plays a pivotal role in
the regulation of adrenal and gonadal steroid hormone biosynthesis. More recent studies …
the regulation of adrenal and gonadal steroid hormone biosynthesis. More recent studies …