Tropane alkaloids: chemistry, pharmacology, biosynthesis and production

KL Kohnen-Johannsen, O Kayser - Molecules, 2019 - mdpi.com
Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in
high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are …

Oxidative cyclization in natural product biosynthesis

MC Tang, Y Zou, K Watanabe, CT Walsh… - Chemical …, 2017 - ACS Publications
Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Functional diversity of 2-oxoglutarate/Fe (II)-dependent dioxygenases in plant metabolism

SC Farrow, PJ Facchini - Frontiers in plant science, 2014 - frontiersin.org
Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite
of enzymes are the 2-oxoglutarate/Fe (II)-dependent dioxygenases (2-ODDs). Cytochromes …

Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures

L Zhang, R Ding, Y Chai, M Bonfill… - Proceedings of the …, 2004 - National Acad Sciences
Scopolamine is a pharmaceutically important tropane alkaloid extensively used as an
anticholinergic agent. Here, we report the simultaneous introduction and overexpression of …

Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition.

DJ Yun, T Hashimoto… - Proceedings of the …, 1992 - National Acad Sciences
The tropane alkaloid scopolamine is a medicinally important anticholinergic drug present in
several solanaceous plants. Hyoscyamine 6 beta-hydroxylase (EC 1.14. 11.11) catalyzes …

Alkaloid biogenesis: molecular aspects.

T Hashimoto, Y Yamada - 1994 - cabidigitallibrary.org
The biosynthesis of alkaloid groups for which the enzymes and genes involved have been
characterized is reviewed in the following sections: biosynthetic enzymes and genes …

[图书][B] Metabolic engineering of plant secondary metabolism

R Verpoorte, AW Alfermann - 2000 - books.google.com
Plant secondary metabolism is an economically important source of fine chemicals, such as
drugs, insecticides, dyes, flavours, and fragrances. Moreover, important traits of plants such …

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

MH Rabinowitz - Journal of medicinal chemistry, 2013 - ACS Publications
Hypoxia-inducible factor (HIF) is an oxygen-sensitive dimeric transcription factor that
responds to pathophysiologically low O2 tensions via up-regulation, which leads to an …

Production of tropane alkaloids in genetically engineered root cultures

T Hashimoto, DJ Yun, Y Yamada - Phytochemistry, 1993 - Elsevier
Hyoscyamine 6β-hydroxylase catalyses the oxidative reactions in the biosynthetic pathway
leading from hyoscyamine to scopolamine. The hydroxylase gene of Hyoscyamus niger was …

Role of plant growth promoting rhizobacteria on antioxidant enzyme activities and tropane alkaloid production of Hyoscyamus niger under water deficit stress

M Ghorbanpour, M Hatami… - Turkish Journal of …, 2013 - journals.tubitak.gov.tr
This study examined the effects of inoculation with 2 rhizobacteria strains, Pseudomonas
putida (PP) and Pseudomonas fluorescens (PF), on growth parameters, chlorophyll, proline …