Epstein–Barr virus and multiple sclerosis
SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …
established causal role in several cancers. Recent studies have provided compelling …
B cells in multiple sclerosis—from targeted depletion to immune reconstitution therapies
MT Cencioni, M Mattoscio, R Magliozzi… - Nature Reviews …, 2021 - nature.com
Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …
Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy
F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …
between heritable and environmental factors. Mounting evidence from different fields of …
The role of infections in multiple sclerosis
M Marrodan, L Alessandro, MF Farez… - Multiple Sclerosis …, 2019 - journals.sagepub.com
Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune
diseases, may be triggered by microbial infections. Pathogens associated with development …
diseases, may be triggered by microbial infections. Pathogens associated with development …
Systematic review and meta-analysis of the association between Epstein–Barr virus, multiple sclerosis and other risk factors
Background: Epstein–Barr virus (EBV) infection is thought to play a central role in the
development of multiple sclerosis (MS). If causal, it represents a target for interventions to …
development of multiple sclerosis (MS). If causal, it represents a target for interventions to …
The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis
C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …
Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy
MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …
central nervous system (CNS) causing progressive disability. Many observations implicate …
Identification of potential inhibitors against Epstein–Barr virus nuclear antigen 1 (EBNA1): An insight from docking and molecular dynamic simulations
Epstein–Barr virus (EBV), a known tumorigenic virus, is associated with various
neuropathies, including multiple sclerosis (MS). However, there is no anti-EBV FDA …
neuropathies, including multiple sclerosis (MS). However, there is no anti-EBV FDA …
HLA alleles modulate EBV viral load in multiple sclerosis
S Agostini, R Mancuso, FR Guerini, S D'Alfonso… - Journal of translational …, 2018 - Springer
Background The etiopathology of multiple sclerosis (MS) is believed to include genetic and
environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated …
environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated …
EBNA1 inhibitors block proliferation of spontaneous lymphoblastoid cell lines from patients with multiple sclerosis and healthy controls
MCG Monaco, SS Soldan, C Su, A Clauze… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that
establishes lifelong latency in memory B cells and has been identified as a major risk factor …
establishes lifelong latency in memory B cells and has been identified as a major risk factor …