Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

B cells in multiple sclerosis—from targeted depletion to immune reconstitution therapies

MT Cencioni, M Mattoscio, R Magliozzi… - Nature Reviews …, 2021 - nature.com
Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

The role of infections in multiple sclerosis

M Marrodan, L Alessandro, MF Farez… - Multiple Sclerosis …, 2019 - journals.sagepub.com
Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune
diseases, may be triggered by microbial infections. Pathogens associated with development …

Systematic review and meta-analysis of the association between Epstein–Barr virus, multiple sclerosis and other risk factors

BM Jacobs, G Giovannoni, J Cuzick… - Multiple sclerosis …, 2020 - journals.sagepub.com
Background: Epstein–Barr virus (EBV) infection is thought to play a central role in the
development of multiple sclerosis (MS). If causal, it represents a target for interventions to …

The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …

Identification of potential inhibitors against Epstein–Barr virus nuclear antigen 1 (EBNA1): An insight from docking and molecular dynamic simulations

S Jakhmola, NA Jonniya, MF Sk, A Rani… - ACS Chemical …, 2021 - ACS Publications
Epstein–Barr virus (EBV), a known tumorigenic virus, is associated with various
neuropathies, including multiple sclerosis (MS). However, there is no anti-EBV FDA …

HLA alleles modulate EBV viral load in multiple sclerosis

S Agostini, R Mancuso, FR Guerini, S D'Alfonso… - Journal of translational …, 2018 - Springer
Background The etiopathology of multiple sclerosis (MS) is believed to include genetic and
environmental factors. Human leukocyte antigen (HLA) alleles, in particular, are associated …

EBNA1 inhibitors block proliferation of spontaneous lymphoblastoid cell lines from patients with multiple sclerosis and healthy controls

MCG Monaco, SS Soldan, C Su, A Clauze… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that
establishes lifelong latency in memory B cells and has been identified as a major risk factor …