Admission hyperglycemia complicates approximately one-third of acute ischemic strokes
and is associated with a worse clinical outcome. Both human and animal studies have …

Background Molecular mechanisms of neuroprotection that lead to ischaemic tolerance are
incompletely understood. Identification of genes involved in the process would provide …

Abstract Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the
cardiovascular system with a range of diverse, sometimes opposing, functions. Through the …

Up‐regulation of cyclooxygenase (COX)‐2 exacerbates neuronal injury after cerebral
ischemia and contributes to neuronal cell death. The present study clarifies the function of …

The Janus-kinase (JAK) and signal transducer activator of transcription (STAT) signalling
pathways regulate gene expression and control various factors involved in normal …

Ischemic stroke is caused when blood flow to the brain is hampered, leading to instant
deficiency of nutrients and oxygen required for normal brain functioning. Reperfusion can …

Many brain disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral
sclerosis (ALS), Huntington, stroke, head trauma, and infection, are associated with …

We have previously shown that estrogen treatment increases cerebrovascular
cyclooxygenase-1, prostacyclin synthase, and production of prostacyclin. Therefore …

Objective—To determine the role of prostacyclin (PGI2) in protecting endothelial cells (ECs)
from apoptosis and elucidate the protective mechanism. Methods and Results—To evaluate …

Several studies suggest that cyclooxygenase (COX)‐2 plays a pivotal role in the progression
of ischaemic brain damage. In the present study, we investigated the effects of selective …