Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions
W Ma, CL Del Rio, L Qi, M Prodanovic… - Proceedings of the …, 2024 - National Acad Sciences
Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity …
Danicamtiv increases myosin recruitment and alters cross-bridge cycling in cardiac muscle
BACKGROUND: Modulating myosin function is a novel therapeutic approach in patients with
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that …
The structural OFF and ON states of myosin can be decoupled from the biochemical super-and disordered-relaxed states
There is a growing awareness that both thick-filament and classical thin-filament regulations
play central roles in modulating muscle contraction. Myosin ATPase assays have …
play central roles in modulating muscle contraction. Myosin ATPase assays have …
Right ventricular sarcomere contractile depression and the role of thick filament activation in human heart failure with pulmonary hypertension
Background: Right ventricular (RV) contractile dysfunction commonly occurs and worsens
outcomes in patients with heart failure with reduced ejection fraction and pulmonary …
outcomes in patients with heart failure with reduced ejection fraction and pulmonary …
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation
Structural and functional studies of heart muscle are important to gain insights into the
physiological bases of cardiac muscle contraction and the pathological bases of heart …
physiological bases of cardiac muscle contraction and the pathological bases of heart …
Myosin in autoinhibited off state (s), stabilized by mavacamten, can be recruited via inotropic effectors
Mavacamten is a novel investigational small molecule designed to regulate cardiac function
at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity of …
at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity of …
Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a naturally occurring heart failure condition in humans and
dogs, notably characterized by a reduced contractility and ejection fraction. As the …
dogs, notably characterized by a reduced contractility and ejection fraction. As the …
[HTML][HTML] The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states
There is a growing awareness that both thick filament and classical thin filament regulation
play central roles in modulating muscle contraction. Myosin ATPase assays have …
play central roles in modulating muscle contraction. Myosin ATPase assays have …
[PDF][PDF] Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle
GC Arenas, AY Tu, TC Irving, MA Geeves11… - academia.edu
Modulating myosin function is a novel therapeutic approach in patients with cardiomyopathy.
Detailed mechanism of action of these agents can help predict potential unwanted affects …
Detailed mechanism of action of these agents can help predict potential unwanted affects …