High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …

Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

The fundamental framework of steroidogenesis is similar across steroidogenic cells,
especially in initial mitochondrial steps. For instance, the START domain containing protein …

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex
pathogenesis including protein aggregation and the dysregulation of neuronal transcription …

Background Persistent inflammatory response in the brain can lead to tissue damage and
neurodegeneration. In Alzheimer's disease (AD), there is an aberrant activation of …

Extensive evidence has indicated that a high rate of cholesterol biogenesis and abnormal
neuronal energy metabolism play key roles in Alzheimer's disease (AD) pathogenesis. Here …