Continuous flow synthesis. A pharma perspective

L Malet-Sanz, F Susanne - Journal of medicinal chemistry, 2012 - ACS Publications
The pharmaceutical industry is going through continuous change, and it is only by adapting
to change that it can survive and improve. Enormous pressure to deliver new and successful …

Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

B Gutmann, D Cantillo, CO Kappe - Angewandte Chemie, 2015 - Wiley Online Library
In den letzten Jahren haben Durchflussreaktoren mit Kanalabmessungen im Mikrometer‐
oder Millimeterbereich weitverbreitete Anwendung in der organischen Synthese gefunden …

Advantages and limitations of microwave reactors: from chemical synthesis to the catalytic valorization of biobased chemicals

P Priecel, JA Lopez-Sanchez - ACS Sustainable Chemistry & …, 2018 - ACS Publications
This critical review examines recent scientific and patent literature in the application of
microwave reactors for catalytic transformation of biomass and biomass-derived molecules …

Cofactor NAD (P) H regeneration inspired by heterogeneous pathways

X Wang, T Saba, HHP Yiu, RF Howe, JA Anderson… - Chem, 2017 - cell.com
Biocatalysis can empower chemical, pharmaceutical, and energy industries, where the use
of enzymes facilitates low-energy, sustainable methods of producing high-value chemicals …

The microwave‐to‐flow paradigm: translating high‐temperature batch microwave chemistry to scalable continuous‐flow processes

TN Glasnov, CO Kappe - Chemistry–A European Journal, 2011 - Wiley Online Library
The popularity of dedicated microwave reactors in many academic and industrial
laboratories has produced a plethora of synthetic protocols that are based on this enabling …

Polysilane-immobilized Rh–Pt bimetallic nanoparticles as powerful arene hydrogenation catalysts: Synthesis, reactions under batch and flow conditions and reaction …

H Miyamura, A Suzuki, T Yasukawa… - Journal of the …, 2018 - ACS Publications
Hydrogenation of arenes is an important reaction not only for hydrogen storage and
transport but also for the synthesis of functional molecules such as pharmaceuticals and …

Heterogeneous catalysis mediated cofactor NADH regeneration for enzymatic reduction

X Wang, HHP Yiu - ACS Catalysis, 2016 - ACS Publications
Enzymatic reduction using oxidoreductases is important in commercial chemical production.
This enzymatic action requires a cofactor (eg, NADH) as a hydrogen source that is …

Reworking organic synthesis for the modern age: Synthetic strategies based on continuous-flow addition and condensation reactions with heterogeneous catalysts

WJ Yoo, H Ishitani, Y Saito, B Laroche… - The Journal of Organic …, 2020 - ACS Publications
While organic synthesis carried out in most laboratories uses batch methods, there is
growing interest in modernizing fine chemical synthesis through continuous-flow processes …

[图书][B] Micro reaction technology in organic synthesis

C Wiles, P Watts - 2016 - books.google.com
A valuable resource for the modern synthetic chemist, this broadly applicable book
addresses the multidisciplinary field of micro reaction technology-from novel research …

Metal-free borane-catalyzed highly stereoselective hydrogenation of pyridines

Y Liu, H Du - Journal of the American Chemical Society, 2013 - ACS Publications
A metal-free direct hydrogenation of pyridines was successfully realized by using
homogeneous borane catalysts generated from alkenes and HB (C6F5) 2 via in situ …