The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms

J Sánchez, A Loewe - Frontiers in Physiology, 2022 - frontiersin.org
Computational simulations of cardiac electrophysiology provide detailed information on the
depolarization phenomena at different spatial and temporal scales. With the development of …

Personalized ablation vs. conventional ablation strategies to terminate atrial fibrillation and prevent recurrence

L Azzolin, M Eichenlaub, C Nagel, D Nairn… - Europace, 2023 - academic.oup.com
Aims The long-term success rate of ablation therapy is still sub-optimal in patients with
persistent atrial fibrillation (AF), mostly due to arrhythmia recurrence originating from …

Comparison of various late gadolinium enhancement magnetic resonance imaging methods with high-definition voltage and activation mapping for detection of atrial …

M Eichenlaub, B Mueller-Edenborn, J Minners… - EP …, 2022 - academic.oup.com
Aims Atrial cardiomyopathy (ACM) is associated with increased arrhythmia recurrence rates
after pulmonary vein isolation (PVI). We compare the most common left atrial (LA) late …

Non-invasive and quantitative estimation of left atrial fibrosis based on P waves of the 12-Lead ECG—a large-scale computational study covering anatomical …

C Nagel, G Luongo, L Azzolin, S Schuler… - Journal of Clinical …, 2021 - mdpi.com
The arrhythmogenesis of atrial fibrillation is associated with the presence of fibrotic atrial
tissue. Not only fibrosis but also physiological anatomical variability of the atria and the …

Fibrotic remodeling during persistent atrial fibrillation: In silico investigation of the role of calcium for human atrial myofibroblast electrophysiology

J Sánchez, B Trenor, J Saiz, O Dössel, A Loewe - Cells, 2021 - mdpi.com
During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Differences in atrial substrate localization using late gadolinium enhancement-magnetic resonance imaging, electrogram voltage, and conduction velocity: a cohort …

D Nairn, M Eichenlaub, B Mueller-Edenborn… - Europace, 2023 - academic.oup.com
Aims Electro-anatomical voltage, conduction velocity (CV) mapping, and late gadolinium
enhancement (LGE) magnetic resonance imaging (MRI) have been correlated with atrial …

Comparison of unipolar and bipolar voltage mapping for localization of left atrial arrhythmogenic substrate in patients with atrial fibrillation

D Nairn, H Lehrmann, B Müller-Edenborn… - Frontiers in …, 2020 - frontiersin.org
Background: Presence of left atrial low voltage substrate in bipolar voltage mapping is
associated with increased arrhythmia recurrences following pulmonary vein isolation for …

Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a Hybrid in silico and in vivo Dataset

J Sánchez, G Luongo, M Nothstein, LA Unger… - Frontiers in …, 2021 - frontiersin.org
In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to
decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to …

Modeling the functional heterogeneity and conditions for the occurrence of microreentry in procedurally created atrial fibrous tissue

A Kalinin, V Naumov, S Kovalenko… - Journal of Applied …, 2023 - pubs.aip.org
The occurrence of atrial fibrillation (AF), one of the most socially significant arrhythmias, is
associated with the presence of areas of fibrosis. Fibrosis introduces conduction …