Since the recognition of vitamin A~ as an essential growth factor, about 70 years ago, the
elucidation of its mechanism of action has been a challenging problem to nutritionists …

Publisher Summary This chapter reviews the studies on the mechanism of tumor promotion
in mouse skin by croton oil and phorbol diesters and on the effects of these compounds on …

It is suggested that formation of more polar metabolites of all-trans-retinoic acid (atRA) via
oxidative pathways limits its biological activity. In this report, we investigated the …

Some activities of retinoids on cellular and humoral immunity have been described, but the
available data are conflicting or obtained at concentrations that are toxic in vivo. In this study …

S91 melanoma cells, which are sensitive to retinoic acid and contain a cellular retinoic acid-
binding protein (RABP), were used in an investigation of the possible correlation between …

The synthetic retinoid, etretinate, has been used to treat ten patients with erosive lichen
planus of the oral mucosa. Beneficial effects were minimal, with only a slight decrease in the …

Reverse phase high pressure liquid chromatography was employed to separate the major
products resulting from the hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by …

Protein kinase C (PKC) is activated when a T cell is stimulated by antigen or mitogen: the
binding of receptor and ligand induces hydrolysis of phosphatidylinositol phosphates and …

The solution conformations of chlamydocin, c> r/o (Aib-Phe-D-Pro-L-Aoe), and Ala4-
chlamydocin, cyc/o [Aib-Phe-D-Pro-L-Ala), have been investigated by* H and 13C nuclear …

Previous studies have demonstrated that 12-O-tetradecanoyl phorbol 13-acetate (TPA)
stimulates phosphatidylcholine biosynthesis in HeLa cells. The stimulation was apparently …