The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Exploitation of the full potential offered by ion beams in clinical practice is still hampered by
several sources of treatment uncertainties, particularly related to the limitations of our ability …

The history of Compton cameras began with the detection of radiation sources originally for
applications in astronomy. A Compton camera is a promising γ-ray detector that operates in …

Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

Background and purpose Motivated by first animal trials showing the normal tissue
protecting effect of electron and photon Flash irradiation, ie at mean dose rates of 100 Gy/s …

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-
beams using the prompt gamma-ray spectroscopy method. The detection system consists of …

We tested the ability of a single Compton camera (CC) to produce 3-dimensional (3D)
images of prompt gammas (PGs) emitted during the irradiation of a tissue-equivalent plastic …

Compton imaging exploits inelastic scattering, known as Compton scattering, using a
Compton camera consisting of a scatterer detector in the front layer and an absorber …

Objective. In this study we introduce spatiotemporal emission reconstruction prompt gamma
timing (SER-PGT), a new method to directly reconstruct the prompt photon emission in the …

In-vivo range verification has been a hot topic in particle therapy for about two decades. In
spite of vast efforts made by research groups all over the world, clinical devices and …