Pulmonary hypertension: a contemporary review

S Johnson, N Sommer, K Cox-Flaherty… - American Journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …

Mitochondrial metabolism, redox, and calcium homeostasis in pulmonary arterial hypertension

S Liang, M Yegambaram, T Wang, J Wang, SM Black… - Biomedicines, 2022 - mdpi.com
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated
pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to …

[HTML][HTML] The role of the redox enzyme p66Shc in biological aging of the lung

CFG Castro, C Nardiello, S Hadzic… - Aging and …, 2024 - ncbi.nlm.nih.gov
The mitochondrial adaptor protein p66Shc has been suggested to control life span in mice
via the release of hydrogen peroxide. However, the role of p66Shc in lung aging remains …

Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets

Y Geng, Y Hu, F Zhang, Y Tuo, R Ge, Z Bai - Frontiers in Physiology, 2023 - frontiersin.org
Mitochondria are the centrol hub for cellular energy metabolisms. They regulate fuel
metabolism by oxygen levels, participate in physiological signaling pathways, and act as …

SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy

Y Li, X Wei, R Xiao, YJ Chen, X Tianxin… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs)
and consequent pulmonary vascular remodeling are the crucial pathological features of …

PDK1 upregulates PINK1-mediated pulmonary endothelial cell mitophagy during hypoxia-induced pulmonary vascular remodeling

J Wang, Y Zhang, Y Luo, ML Liu, W Niu, ZC Li… - Molecular biology …, 2023 - Springer
Background Hypoxic pulmonary hypertension (HPH) is a complication of lung diseases with
pulmonary vascular remodeling, although the underlying molecular mechanisms have not …

[PDF][PDF] The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung

AG Arnhold, W Seeger, R Schulz… - Aging and …, 2024 - scholar.archive.org
The mitochondrial adaptor protein p66Shc has been suggested to control life span in mice
via the release of hydrogen peroxide. However, the role of p66Shc in lung aging remains …

Pulmonary Hypertension: Unveiling Molecular Mechanisms, Diagnosis, and Therapeutic Targets

M Gredic, S Hadzic - Journal of Personalized Medicine, 2023 - mdpi.com
Pulmonary hypertension (PH) is a progressive and life-threatening disease characterized by
increased pulmonary arterial pressure, which leads to right heart hypertrophy and eventually …

The role and mechanism of FTO in pulmonary vessels

J Xu, D Yin, W Zhang, Y Xu - Biotechnology and Genetic …, 2023 - Taylor & Francis
Pulmonary vascular remodeling (PVR) is the main factor of pulmonary hypertension (PH).
The pathological characteristics of PVR are vascular smooth muscle hyperplasia …

Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis

B Vastrad, C Vastrad - bioRxiv, 2022 - biorxiv.org
Bipolar disorder (BD), also known as psychiatric disorder, affects millions of people all over
the world. The aim of this investigation was to screen and verify hub genes involved in BD as …