Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

The elderly consume a disproportionate amount of prescription and nonprescription
medications. Alterations in physiology, polypharmacy, multiple prescribers, and other factors …

More than a decade has passed since it was unintentionally discovered that grapefruit juice
interacts with certain drugs. The coadministration of these drugs with grapefruit juice can …

Grapefruit juice can alter oral drug pharmacokinetics by different mechanisms. Irreversible
inactivation of intestinal cytochrome P450 (CYP) 3A4 is produced by commercial grapefruit …

Grapefruit juice and grapefruit product consumption have potential health benefits; however,
their intake is also associated with interactions with certain drugs, including calcium channel …

To evaluate the pharmacokinetics and adverse effects of medicinal herbs, as well as clinical
evidence of herb-drug interactions. Electronic searches were conducted in multiple …

This is our first presentation of Great Drug Classes, and we start with a description of
phosphodiesterase type 5 inhibitors and their use in erectile dysfunction. This is an in‐depth …

OBJECTIVE To provide an update on the efficacy and safety of tadalafil, a
phosphodiesterase‐5 inhibitor, in the treatment of erectile dysfunction (ED). PATIENTS AND …

Differences in the clinical pharmacology of the 3 currently available oral phosphodiesterase‐
5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, are largely determined by their …

The use of herbal products in the UK is increasing, and over-the-counter herbal
supplements are perceived by the public as' safe'and'harmless'. Although the majority of …