A review of computational fluid dynamics analysis of blood pumps

M Behbahani, M Behr, M Hormes… - European Journal of …, 2009 - cambridge.org
Ventricular assist devices (VADs) provide long-and short-term support to chronically ill heart
disease patients; these devices are expected to match the remarkable functionality of the …

Lagrangian postprocessing of computational hemodynamics

SC Shadden, A Arzani - Annals of biomedical engineering, 2015 - Springer
Recent advances in imaging, modeling, and computing have rapidly expanded our
capabilities to model hemodynamics in the large vessels (heart, arteries, and veins). This …

Evaluation of Eulerian and Lagrangian models for hemolysis estimation

ME Taskin, KH Fraser, T Zhang, C Wu, BP Griffith… - ASAIO …, 2012 - journals.lww.com
Hemolysis caused by flow-induced mechanical damage to red blood cells is still a problem
in medical devices such as ventricular assist devices (VADs), artificial lungs, and …

Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress

Z Chen, NK Mondal, J Ding, SC Koenig… - Molecular and cellular …, 2015 - Springer
The purpose of this study was to investigate the influence of non-physiological high shear
stress on activation and shedding of platelet GP IIb/IIIa receptors. The healthy donor blood …

Computational characterization of flow and hemolytic performance of the UltraMag blood pump for circulatory support

ME Taskin, KH Fraser, T Zhang, B Gellman… - Artificial …, 2010 - Wiley Online Library
Abstract The Levitronix UltraMag blood pump is a next generation, magnetically suspended
centrifugal pump and is designed to provide circulatory support for pediatric and adult …

Quantification of shear‐induced platelet activation: high shear stresses for short exposure time

J Ding, Z Chen, S Niu, J Zhang, NK Mondal… - Artificial …, 2015 - Wiley Online Library
Thrombosis and thromboembolism are the life‐threatening clinical complications for patients
supported or treated with prosthetic cardiovascular devices. The high mechanical shear …

Prediction of mechanical hemolysis in medical devices via a Lagrangian strain‐based multiscale model

M Nikfar, M Razizadeh, J Zhang, R Paul, ZJ Wu… - Artificial …, 2020 - Wiley Online Library
This work introduces a new Lagrangian strain‐based model to predict the shear‐induced
hemolysis in biomedical devices. Current computational models for device‐induced …

Shear-induced platelet receptor shedding by non-physiological high shear stress with short exposure time: glycoprotein Ibα and glycoprotein VI

Z Chen, NK Mondal, J Ding, J Gao, BP Griffith… - Thrombosis research, 2015 - Elsevier
Introduction The structural integrity of platelet receptors is essential for platelets to function
normally in hemostasis and thrombosis in response to physiological and pathological …

The impact of shear stress on device‐induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation

Z Chen, J Zhang, T Li, D Tran, BP Griffith… - Artificial organs, 2020 - Wiley Online Library
The aim of this study was to examine the impact of the nonphysiological shear stress (NPSS)
on platelet hemostatic function relevant to thrombosis and bleeding in mechanically assisted …

Durable, flexible, superhydrophobic and blood-repelling surfaces for use in medical blood pumps

Z Li, BL Nguyen, YC Cheng, J Xue… - Journal of Materials …, 2018 - pubs.rsc.org
Extracorporeal blood pumps expose blood to high stresses and can cause blood damage or
clotting, leading to serious complications and death. One possible solution is to use …