Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-
stage neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were …

Peripheral neuroblastic tumors (neuroblastoma, ganglioneuroblastoma and
ganglioneuroma) are heterogeneous and their diverse and wide range of clinical behaviors …

Despite intensive multimodal therapy, the survival rate for high risk neuroblastoma (HR-NB)
remains< 50%. Most cases initially respond to treatment but almost half will subsequently …

In recent years, much research has been carried out to identify the biological and genetic
characteristics of the neuroblastoma (NB) tumor in order to precisely define the prognostic …

Telomere maintenance plays important roles in genome stability and cell proliferation.
Tumor cells acquire replicative immortality by activating a telomere-maintenance …

There is unequivocal evidence that telomeres are crucial for cellular homeostasis and that
telomere dysfunction can elicit genome instability and potentially initiate events that …

Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous
system. High-risk NB is characterized by MYCN amplification and human telomerase …

Purpose Our telomere biology study of neuroblastomas (NBLs) has revealed that
unfavorable NBLs acquired telomere stabilization by telomerase activation or ALT …

Aggressive, high‐risk neuroblastoma (NB) exhibits an immature differentiation state,
profound epigenetic dysregulation and high telomerase activity. It has been suggested that …