Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino
acids. A large number of natural cyclopeptides have been reported to be highly effective …

After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the
efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR …

The natural products of heterobranch molluscs display a huge variability both in structure
and in their bioactivity. Despite the considerable lack of information, it can be observed from …

The chemical investigation of marine mollusks has led to the isolation of a wide variety of
bioactive metabolites, which evolved in marine organisms as favorable adaptations to …

Doliculide belongs to a group of marine cyclodepsipeptides with interesting biological
properties. Apart from a halogenated dipeptide, a polyketide fragment containing 5 …

Access to enantiopure complex molecular structures is crucial for the development of new
drugs as well as agents used in crop-protection. In this regard, numerous asymmetric …

A convergent and flexible strategy for the stereoselective total synthesis of the reported
structure of baulamycin A and its congeners has been developed for the first time. Synthetic …

Regioselectivity is a crucial issue in Baeyer–Villiger (BV) oxidation. To date, few reports
have addressed asymmetric BV oxidation of 3-substituted cycloketones due to the high …

(−)-Doliculide, a marine cyclodepsipeptide derived from the Japanese sea hare, Dolabella
auricularia, exhibits potent cytotoxic properties, sparking interest in the field of synthetic …

Sea hares (family Aplysiidae) are a rich source of bioactive substances. Especially, over the
past 40 years, the genera Aplysia and Dolabella have afforded numerous bioactive …