Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Rationale: There is currently no effective pharmacological treatment for obstructive sleep
apnea (OSA). Recent investigations indicate that drugs with noradrenergic and …

OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient's own phenotypic causes (“traits”) if a clinically applicable approach were …

Background We recently showed that administration of the combination of the noradrenergic
drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep greatly reduced …

Key points Recent animal and human physiology studies indicate that noradrenergic and
muscarinic processes are key mechanisms that mediate pharyngeal muscle control during …

Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options.
To date there is no approved pharmacotherapy for this disorder, but several attempts have …

Mandibular advancement device (MAD) therapy is the most commonly used non-continuous
positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA). Although OSA …