Abstract Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening
condition characterized by markedly elevated circulating levels of low-density lipoprotein …

Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …

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não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …

Homozygous familial hypercholesterolemia (HoFH) is an autosomal co-dominant disease
resulting from mutations in both copies of the low-density lipoprotein receptor (LDLR) gene …

Familial hypercholesterolemia (FH) is characterized by raised serum LDL cholesterol levels,
which result in excess deposition of cholesterol in tissues, leading to accelerated …

PCSK9 is the ninth member of the proprotein convertase (PC) family. Some of its natural
mutations have been genetically associated with the development of a dominant form of …

Dyslipidemia is a commonly encountered clinical condition and is an important determinant
of cardiovascular disease. Although secondary factors play a role in clinical expression …

Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism resulting
in elevated serum low-density lipoprotein (LDL) cholesterol levels leading to increased risk …

Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-
density lipoprotein (LDL) cholesterol and premature cardiovascular disease, with a …

Familial Hypercholesterolemia (FH) is a common cause of premature cardiovascular
disease and is often undiagnosed in young people. Although the disease is diagnosed …