Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Drug development suffers from a lack of predictive and human-relevant in vitro models.
Organ-on-chip (OOC) technology provides advanced culture capabilities to generate …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …

e2 Hypertension February 2018 target> 1 kinase receptor allowing for a broader indication
for use but with a greater potential for off-target effects. VSP inhibitors have been …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Traumatic spinal cord injury (SCI) has widespread physiological effects beyond the
disruption of sensory and motor function, notably the loss of normal autonomic and …