Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments
Microfluidic devices allow for precise control of the cellular and noncellular
microenvironment at physiologically relevant length-and time-scales. These devices have …
microenvironment at physiologically relevant length-and time-scales. These devices have …
A review of chemical gradient systems for cell analysis
Microfluidic spatial and temporal gradient generators have played an important role in many
biological assays such as in the analysis of wound healing, inflammation, and cancer …
biological assays such as in the analysis of wound healing, inflammation, and cancer …
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
Sonic hedgehog (Shh) plays essential roles in developmental events such as cell fate
specification and axon guidance. Shh induces cell fate specification through canonical Shh …
specification and axon guidance. Shh induces cell fate specification through canonical Shh …
A high-throughput microfluidic assay to study neurite response to growth factor gradients
Studying neurite guidance by diffusible or substrate bound gradients is challenging with
current techniques. In this study, we present the design, fabrication and utility of a …
current techniques. In this study, we present the design, fabrication and utility of a …
Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion
T Fothergill, ALS Donahoo, A Douglass… - Cerebral …, 2014 - academic.oup.com
The left and right sides of the nervous system communicate via commissural axons that
cross the midline during development using evolutionarily conserved molecules. These …
cross the midline during development using evolutionarily conserved molecules. These …
Remote modulation of neural activities via near-infrared triggered release of biomolecules
The capability to remotely control the release of biomolecules provides an unique
opportunity to monitor and regulate neural signaling, which spans extraordinary spatial and …
opportunity to monitor and regulate neural signaling, which spans extraordinary spatial and …
Can molecular gradients wire the brain?
GJ Goodhill - Trends in neurosciences, 2016 - cell.com
Concentration gradients are believed to play a key role in guiding axons to their appropriate
targets during neural development. However, there are fundamental physical constraints on …
targets during neural development. However, there are fundamental physical constraints on …
Integration of shallow gradients of Shh and Netrin-1 guides commissural axons
During nervous system development, gradients of Sonic Hedgehog (Shh) and Netrin-1
attract growth cones of commissural axons toward the floor plate of the embryonic spinal …
attract growth cones of commissural axons toward the floor plate of the embryonic spinal …
Device for high throughput investigations of multi-cellular interactions
Provided herein are microfluidic devices that can be used as a 3D bioassay, eg, for drug
screening, personalized medicine, tissue engineering, wound healing, and other …
screening, personalized medicine, tissue engineering, wound healing, and other …
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Understanding how axons are guided to target locations within the brain is of fundamental
importance for neuroscience, and is a widely studied area of research. Biologists have an …
importance for neuroscience, and is a widely studied area of research. Biologists have an …