Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to
sarcomere insufficiency. However, it remains mechanistically unclear how these mutations …

Tumor cell migration is essential for invasion and dissemination from primary solid tumors
and for the establishment of lethal secondary metastases at distant organs. In vivo and in …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

The mechanical wiring between cells and their surroundings is fundamental to the
regulation of complex biological processes during tissue development, repair or pathology …

Historically the culture of mammalian cells in the laboratory has been performed on planar
substrates with media cocktails that are optimized to maintain phenotype. However, it is …

Quantifying small, rapidly evolving forces generated by cells is a major challenge for the
understanding of biomechanics and mechanobiology in health and disease. Traction force …