Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019)
C Sánchez-Martínez, MJ Lallena… - Bioorganic & medicinal …, 2019 - Elsevier
Sustained proliferative capacity and gene dysregulation are hallmarks of cancer. In
mammalian cells, cyclin-dependent kinases (CDKs) control critical cell cycle checkpoints …
mammalian cells, cyclin-dependent kinases (CDKs) control critical cell cycle checkpoints …
PROTACs to address the challenges facing small molecule inhibitors
P Martín-Acosta, X Xiao - European journal of medicinal chemistry, 2021 - Elsevier
Small molecule inhibitors of proteins represent important medicines and critical chemical
tools to investigate the biology of the target proteins. Advances in various-omics …
tools to investigate the biology of the target proteins. Advances in various-omics …
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
Progress in targeted therapeutic drugs for oral squamous cell carcinoma
L Liu, J Chen, X Cai, Z Yao, J Huang - Surgical oncology, 2019 - Elsevier
With the rapid development of biomedicine, people have a deeper understanding with the
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …
Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors
AM El-Naggar, MA El-Hashash, EB Elkaeed - Bioorganic Chemistry, 2021 - Elsevier
One current approach in the treatment of cancer is the inhibition of cyclin dependent kinase
(CDK) enzymes with small molecules. CDK are a class of enzymes, which catalyze the …
(CDK) enzymes with small molecules. CDK are a class of enzymes, which catalyze the …
Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
In the current work, a hybridisation strategy was adopted between the privileged building
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …
CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells
Serine/threonine kinases called cyclin-dependent kinases (CDKs) interact with cyclins and
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
CDK inhibitors (CKIs) to control the catalytic activity. CDKs are essential controllers of RNA …
A comprehensive insight on the recent development of cyclic dependent kinase inhibitors as anticancer agents
BN Marak, J Dowarah, L Khiangte, VP Singh - European Journal of …, 2020 - Elsevier
Cancer is one of the major leading causes of death worldwide despite many breakthroughs
in the development of novel anticancer drugs. The heterodimer CDK-Cyclin complex plays …
in the development of novel anticancer drugs. The heterodimer CDK-Cyclin complex plays …
[HTML][HTML] An insight into the risk factors of brain tumors and their therapeutic interventions
Brain tumors are an abnormal growth of cells in the brain, also known as multifactorial
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …
Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets
Background Proteomic characterization of cancers is essential for a comprehensive
understanding of key molecular aberrations. However, proteomic profiling of a large cohort …
understanding of key molecular aberrations. However, proteomic profiling of a large cohort …