Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Uterine leiomyomas are the most common tumors of the female genital tract, affecting 50%
to 70% of females by the age of 50. Despite their prevalence and enormous medical and …

Highlights•Race/ethnicity is the most consistent factor associated with fibroid
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …

Uterine leiomyoma is the most common tumor of the female reproductive system and
originates from a single transformed myometrial smooth muscle cell. Despite the immense …

COVID-19 is caused by the SARS-CoV-2 virus, which enters target cells via interactions with
ACE2 and TMPRSS2. Here, we show AKT serine/threonine kinase-dependent epigenetic …

Uterine leiomyomas or fibroids are the most common tumors of the female reproductive tract.
Estrogen (E 2), a steroid-derived hormone, and its receptors (ERs), particularly ER-α, are …

Background Manganese overexposure can induce neurotoxicity, lead to manganism and
result in clinical manifestations similar to those of parkinsonism. However, the underlying …

BACKGROUND Human leiomyomata (fibroids) are benign tumors of the uterus, represent
the most common neoplasms of reproductive-aged women and have a prevalence of∼ 70 …

Introduction Uterine fibroids are the most common benign gynecological tumors affecting
women of reproductive ages. Although surgery is the definitive treatment choice, several …