How cancer hijacks the body's homeostasis through the neuroendocrine system
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides
AT Slominski, RM Slominski… - … of Physiology-Cell …, 2022 - journals.physiology.org
The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …
largest organ in the human body and it plays a crucial role in the regulation of the body's …
The serum vitamin D metabolome: What we know and what is still to discover
RC Tuckey, CYS Cheng, AT Slominski - The Journal of steroid biochemistry …, 2019 - Elsevier
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …
phototransformation in the skin, is a prohormone important in human health. The most …
Vitamin D receptor (s): In the nucleus but also at membranes?
MA Zmijewski, C Carlberg - Experimental Dermatology, 2020 - Wiley Online Library
The genomic actions of the vitamin D are mediated via its biologically most potent metabolite
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …
[图书][B] Melatoninergic system in the skin
Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …
Photoprotective properties of vitamin D and lumisterol hydroxyderivatives
AT Slominski, A Chaiprasongsuk, Z Janjetovic… - Cell biochemistry and …, 2020 - Springer
We have previously described new pathways of vitamin D3 activation by CYP11A1 to
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
produce a variety of metabolites including 20 (OH) D3 and 20, 23 (OH) 2 D3. These can be …
Molecular mechanisms of neurogenic inflammation of the skin
L Marek-Jozefowicz, B Nedoszytko… - International Journal of …, 2023 - mdpi.com
The skin, including the hypodermis, is the largest body organ and is in constant contact with
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …
the environment. Neurogenic inflammation is the result of the activity of nerve endings and …
Key role of CRF in the skin stress response system
AT Slominski, MA Zmijewski, B Zbytek… - Endocrine …, 2013 - academic.oup.com
The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …
Steroidogenesis in the skin: implications for local immune functions
A Slominski, B Zbytek, G Nikolakis, PR Manna… - The Journal of steroid …, 2013 - Elsevier
The skin has developed a hierarchy of systems that encompasses the skin immune and
local steroidogenic activities in order to protect the body against the external environment …
local steroidogenic activities in order to protect the body against the external environment …
Novel activities of CYP11A1 and their potential physiological significance
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …