BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …

High-order chromatin structure plays important roles in gene expression regulation.
Knowledge of the dynamics of 3D chromatin structures during mammalian embryo …

A sperm-driven micromotor is presented as a targeted drug delivery system, which is
appealing to potentially treat diseases in the female reproductive tract. This system is …

Recent advances in the versatility and sophistication of design, fabrication, and control
methods of mobile microrobots could have a transforming impact on future healthcare …

Understanding the extent of genomic transcription and its functional relevance is a central
goal in genomics research. However, detailed genome-wide investigations of transcriptome …

BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …

Haploid round spermatids undergo a remarkable transformation during spermiogenesis.
The nucleus polarizes to one side of the cell as the nucleus condenses and elongates, and …

BACKGROUND There has been substantial interest in assessing whether RNAs (mRNAs
and sncRNAs, ie small non-coding) delivered from mammalian spermatozoa play a …

Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …