Water as the often neglected medium at the interface between materials and biology

BL Dargaville, DW Hutmacher - Nature Communications, 2022 - nature.com
Despite its apparent simplicity, water behaves in a complex manner and is fundamental in
controlling many physical, chemical and biological processes. The molecular mechanisms …

Design of polymeric biomaterials: The “intermediate water concept”

M Tanaka, S Kobayashi, D Murakami… - Bulletin of the …, 2019 - academic.oup.com
When biomaterials come into contact with biological fluids, water molecules immediately
adsorb onto the surface of the materials. To understand the origin of the crucial roles of …

Fluorine-containing bio-inert polymers: Roles of intermediate water

R Koguchi, K Jankova, M Tanaka - Acta Biomaterialia, 2022 - Elsevier
Fluorine-containing polymers are used not only in industrial processes but also in medical
applications, because they exhibit excellent heat, weather, and chemical resistance. As …

The intermediate water concept for pioneering polymeric biomaterials: A review and update

S Nishimura, M Tanaka - Bulletin of the Chemical Society of …, 2023 - academic.oup.com
Polymeric biomaterials are often used in water and hydration water molecules with different
mobilities, such as non-freezing water, intermediate water, and free water, are formed on …

Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode

M Mabrouk, HH Beherei, Y Tanaka, M Tanaka - Biomaterials Advances, 2022 - Elsevier
The hydration state of bioactive glass materials and its relationship with their biocompatibility
have been receiving attention. In this research, silver-containing bioactive glasses …

Investigating the intermediate water feature of hydrated titanium containing bioactive glass

M Mabrouk, HH Beherei, Y Tanaka… - International journal of …, 2021 - mdpi.com
Intermediate water (IW) in hydrated bioactive glasses remains uninvestigated. We obtained
titanium (Ti)-containing bioactive glasses (BGTs)(Ti at 5%, 7.5% and 10% of the glass …

Elucidating the feature of intermediate water in hydrated poly (ω-methoxyalkyl acrylate) s by molecular dynamics simulation and differential scanning calorimetry …

AT Kuo, T Sonoda, S Urata, R Koguchi… - ACS Biomaterials …, 2020 - ACS Publications
Intermediate water (IW) has been reported to play an important role in nonthrombogenicity of
biomaterials. However, clear insights into the IW in the hydrated polymer are still debated. In …

Effects of side-chain spacing and length on hydration states of poly (2-methoxyethyl acrylate) analogues: A molecular dynamics study

AT Kuo, S Urata, R Koguchi, T Sonoda… - ACS Biomaterials …, 2021 - ACS Publications
Hydration states of polymers are known to directly influence the adsorption of biomolecules.
Particularly, intermediate water (IW) has been found able to prevent protein adsorption …

Revealing the hidden dynamics of confined water in acrylate polymers: Insights from hydrogen-bond lifetime analysis

K Shikata, T Kikutsuji, N Yasoshima, K Kim… - The Journal of …, 2023 - pubs.aip.org
Polymers contain functional groups that participate in hydrogen bond (H-bond) with water
molecules, establishing a robust H-bond network that influences bulk properties. This study …

Molecular structure and vibrational spectra of water molecules sorbed in poly (2-methoxyethylacrylate) revealed by molecular dynamics simulation

N Yasoshima, T Ishiyama, M Gemmei-Ide… - The Journal of …, 2021 - ACS Publications
Molecular dynamics (MD) simulations of water sorption in poly (2-methoxyethylacrylate)(
PMEA) are carried out to elucidate the hydrogen bonding (H-bonding) structures of the water …