Over the past few years, substantial advances have been made in understanding the
pathogenesis, evolution, and complexity of mast cell neoplasms. New diagnostic and …

Mast Cells, Mastocytosis, and Related Disorders | New England Journal of Medicine Skip to main
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Mastocytosis is a heterogeneous group of neoplasms defined by a numerical increase and
accumulation of clonal mast cells (MCs) in various organ systems. The disease may present …

Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the
expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The …

Overview Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast
cells (MCs) in extra‐cutaneous organs. Diagnosis The major criterion is presence of …

Anaphylaxis is the most severe and frightening of the allergic reactions, placing patients at
high risk and demanding prompt recognition and immediate management by health care …

Background Indolent systemic mastocytosis (ISM) is a clonal mast-cell disease driven by the
KIT D816V mutation. We assessed the efficacy and safety of avapritinib versus placebo, both …

Systemic mastocytosis (SM) has greatly benefited from the broad application of precision
medicine techniques to hematolymphoid neoplasms. Sensitive detection of the recurrent KIT …

To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis
(SM) and to suboptimal responses to diverse therapies, we analyzed 39 KIT D816V mutated …

Mastocytosis is a heterogeneous group of diseases characterized by abnormal proliferation
of mast cells. Systemic mastocytosis (SM), in which abnormal mast cells are present in …